You can wear your compression socks all day by putting them on when getting dressed in the morning, and take them off before bed (unless your doctor advises otherwise).

While flight socks (compression socks) are highly beneficial for long-haul travel to prevent Deep Vein Thrombosis (DVT), they are not intended for 24/7 wear unless specifically prescribed by a doctor for a medical condition like chronic venous insufficiency. In 2026, health experts advise that wearing them continuously can actually be counterproductive. The steady pressure can irritate the skin or even restrict circulation if the socks bunch up or are improperly fitted. Furthermore, your legs need "breathing room" to maintain skin health and natural blood flow when you are horizontal. When sleeping, the gravitational pull on your blood is reduced, making the compression unnecessary for most people. The standard recommendation is to put them on before a flight or a long day on your feet and remove them before going to bed to allow your circulatory system to function without external assistance.