For a domestic-to-domestic connection at Charlotte Douglas International Airport (CLT), a minimum of 45 to 60 minutes is generally sufficient, as the airport is designed in a "hub and spoke" layout where all gates are connected behind security. However, CLT is notorious for long walks between the far end of Concourse A and Concourse E, and the terminal is often very crowded. For peace of mind, a 90-minute layover is ideal. If you are connecting from an international flight to a domestic one, you will need at least 2.5 to 3 hours, as you must clear U.S. Customs, collect your checked bags, re-check them, and go through TSA security again. Charlotte is a major hub for American Airlines, and while they schedule "tight" 35-minute connections, any slight flight delay can result in a missed flight. In 2026, ongoing construction and expansion at CLT mean you should allow extra time to navigate the detours and the busy "moving walkways" in the main atrium.