Situated at the north end of the Las Vegas Strip, Resorts World Las Vegas is four miles from McCarran International Airport, ideally located across from the Las Vegas Convention Center Expansion and adjacent to the Fashion Show Mall.

Resorts World Las Vegas is located on the northern end of the famous Las Vegas Strip, occupying a massive 88-acre site. It is situated directly across the street from the Encore and Wynn Las Vegas resorts, which are its most prominent neighbors to the south. To the north, it sits adjacent to the Circus Circus Hotel & Casino and the Fontainebleau Las Vegas, which opened in late 2023. One of its most strategic neighbors is the Las Vegas Convention Center (LVCC); Resorts World is directly connected to the LVCC via the "Vegas Loop," an innovative underground tunnel system developed by Elon Musk’s Boring Company that uses Tesla vehicles to transport guests in minutes. Behind the property to the west is the Industrial Road corridor and the Echelon site. This location at the "North Strip" was once the site of the legendary Stardust Resort and Casino. Being situated here puts guests within walking distance of Fashion Show Mall while offering a slightly more modern, integrated tech-forward experience compared to the older, more congested central sections of the Las Vegas Strip.