What medicine calms nerves before flying?

People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.



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Your doctor can prescribe you a type of medication known as benzodiazepine, which can calm the nervous system. The most well-known examples are Xanax and Ativan, which act within minutes to relieve anxiety. They last several hours — which is the duration of most cross-country flights, such as Los Angeles to New York.

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The two main medication classes most often prescribed are:
  • Benzodiazepines, such as the antianxiety drugs alprazolam (Xanax®), clonazepam (Klonopin®) and diazepam (Valium®).
  • Selective serotonin reuptake inhibitors, such as paroxetine (Paxil®) or escitalopram (Lexapro®).


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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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While Xanax may be useful for flying on an airplane, it will not help you with your anxiety. It may help in the moment but you will not tackle your fear of flying if you are asleep the whole flight. If you ran out of your medication or left it at home, the anxiety will still exist if you go on an airplane again.

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Does Benadryl Help Anxiety? Although some people say that Benadryl helps their anxiety, it is not approved by the FDA for anxiety symptoms. Therefore, do not take it for anxiety unless your healthcare provider specifically recommends it. The only FDA-approved antihistamine for anxiety is hydroxyzine (Atarax, Vistaril).

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Successful treatment of aviophobia often involves exposure therapy. Participants face their fears, gradually and in a safe space, working their way back into the air.

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Official answer. Ativan and Xanax are both benzodiazepines used for the treatment of anxiety, and both are equally effective for this use. The differences are: Xanax has a quicker onset of effect, but a shorter duration of action (4 to 6 hours) compared with Ativan's 8 hours.

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To ease discomfort, you can take a nonsteroidal anti-inflammatory drug, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), or an analgesic pain reliever, such as acetaminophen (Tylenol, others).

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To prevent motion sickness, the first dose should be taken ½ to 1 hour before starting activity: Adults and children 12 years and over: 1 to 2 tablets every 4-6 hours; do not take more than 8 tablets in 24 hours, or as directed by a doctor.

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I recommend melatonin as a natural supplement to my patients with flight-related anxiety. Melatonin induces sleep and adjusts your circadian clock to help you function better when you reach your destination.

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Licensed therapist Jules Jean-Pierre of Grow Therapy suggests that the more common fears associated with flying are the fears of dying, small spaces (claustrophobia), motion sickness, getting COVID, and judgment from fellow passengers, among others.

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She told the group what worried her. “I am afraid of dying.” Fear of flying, or aviophobia, is an anxiety disorder.

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Treat congestion before your trip
If you're congested from allergies or an upper respiratory infection, it's important to do what you can to resolve the congestion before you fly. Common treatments for congestion include antihistamines, decongestants, and nasal steroid sprays.

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Xanax, a member of the same pharmaceutical family (benzodiazepines) as diazepam, is a strong one. Take it about two to three hours before you fly, and do not mix it with alcohol. There is a risk of dependency, though, with these benzodiazepines, but only if you are taking them more than once a week.

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