Some doctors prescribe anxious fliers with fast-acting anxiety medications like Xanax or Valium, but Farchione warns that you should be aware that each has its own side effects and that you may feel tired for hours after the plane has landed.

To ensure a comfortable and healthy flight, especially for long-haul journeys, your "pre-flight kit" should focus on hydration and circulation. Many travelers find taking a magnesium supplement or a mild herbal tea like chamomile helps with relaxation and "plane jitters." If you are prone to motion sickness, taking an anti-nausea medication like ginger tablets or a pharmaceutical option 30 minutes before boarding is essential. For physical health, consider putting on compression socks before you head to the airport; they help prevent blood pooling and reduce the risk of Deep Vein Thrombosis (DVT). It is also highly recommended to apply a thick moisturizer and lip balm, as cabin humidity often hovers around a bone-dry 10-20%. From a nutritional standpoint, eating a light, protein-rich meal is better than a heavy, salty one, as salt contributes to bloating at high altitudes. If you have a history of ear pain during descent, carrying a pack of gum or "EarPlanes" earplugs can help regulate pressure changes. Finally, always pack a small bottle of hand sanitizer and a travel-size pack of disinfectant wipes to clean your tray table and armrests upon arrival at your seat.