When should I take pseudoephedrine before flying?

In a recent study of adults with a history of recurrent ear pain associated with air travel, the administration of oral pseudoephedrine 30 minutes before flight departure significantly reduced the occurrence of ear pain during the flight.



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To ease discomfort, you can take a nonsteroidal anti-inflammatory drug, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), or an analgesic pain reliever, such as acetaminophen (Tylenol, others).

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If you have sinus pressure during flights then you should bring along a decongestant spray (Oxymetazoline or Phenylephrine), found in the nasal aisle at the drug store, and use it approximately one hour before a flight of any duration.

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If you start to notice this pressure building, you can try some of these strategies:
  1. Take an antihistamine if needed before your flight. ...
  2. Yawn or swallow during takeoff.
  3. Try chewing a piece of gum or candy during takeoff, if yawning and swallowing don't work for you.


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If you suffer from allergies, consider a non-sedating antihistamine instead, such as loratadine (Claritin®) or fexofenadine (Allegra). Claritin and Allegra do not have wait times (after the initial ground trial).

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Breathing in the steam from a hot drink or drinking 5-10 cups of water will help restore the moisture in your nose and will relieve the symptoms of a blocked nose. Mints and menthol chewing gum can also help relieve your blocked nose. Use a nasal spray which contains a decongestant half an hour before flying.

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As a general rule, flying with a sinus infection and a congested nose is not advised. Changes in cabin air pressure affect the air inside and outside of your head. As a result, clogged sinuses, which prevent you from equalizing pressure differences, can be excruciatingly painful.

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These include any hormone-based drugs, like the contraceptive pill and some fertility medicines, and drugs used to prevent heart attack and stroke. Antihistamines should also not be used to help passengers sleep during a flight.

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Treat congestion before your trip
If you're congested from allergies or an upper respiratory infection, it's important to do what you can to resolve the congestion before you fly. Common treatments for congestion include antihistamines, decongestants, and nasal steroid sprays.

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